Article
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Molecular psychiatry - 1 Nov 2009
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage C A, Huot L, Bensemain F, Laumet G, Ayral A M, Fievet N, Hauw J J, DeKosky S T, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues J F, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh M I, Amouyel P, Lambert J C
Abstract excerpt
The only recognized genetic determinant of the common forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). To identify new candidate genes, we recently performed transcriptomic analysis of 2741 genes in chromosomal regions of interest using brain tissue of AD cases and controls. From 82 differentially expressed genes, 1156 polymorphisms were genotyped in two independent...
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