Article
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease.
Molecular psychiatry - 1 Nov 2009
Chapuis J, Hot D, Hansmannel F, Kerdraon O, Ferreira S, Hubans C, Maurage C A, Huot L, Bensemain F, Laumet G, Ayral A M, Fievet N, Hauw J J, DeKosky S T, Lemoine Y, Iwatsubo T, Wavrant-Devrièze F, Dartigues J F, Tzourio C, Buée L, Pasquier F, Berr C, Mann D, Lendon C, Alpérovitch A, Kamboh M I, Amouyel P, Lambert J C
Abstract excerpt
The only recognized genetic determinant of the common forms of Alzheimer's disease (AD) is the epsilon 4 allele of the apolipoprotein E gene (APOE). To identify new candidate genes, we recently performed transcriptomic analysis of 2741 genes in chromosomal regions of interest using brain tissue o...
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