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Article

Validating GWAS Variants from Microglial Genes Implicated in Alzheimer's Disease.

Journal of molecular neuroscience : MN - 1 Jun 2017

Dos Santos Lígia Ramos, Pimassoni Lúcia Helena Sagrillo, Sena Geralda Gillian Silva, Camporez Daniela, Belcavello Luciano, Trancozo Maíra, Morelato Renato Lírio, Errera Flavia Imbroisi Valle, Bueno Maria Rita Passos, de Paula Flavia

Abstract excerpt

Late-onset Alzheimer's disease (LOAD) is a multifactorial neurodegenerative disorder that corresponds to most Alzheimer's disease (AD) cases. Inflammation is frequently related to AD, whereas microglial cells are the major phagocytes in the brain and mediate the removal of Aβ peptides. Microglial cell dsyregulation might contribute to the formation of amyloid plaques, a hallmark of AD. Genome-wide association...

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Identifiers

PMID: 28477215
DOI: 10.1007/s12031-017-0928-7

Genes

ABCA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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