Article
The effect of IL4 +33C/T polymorphism on risk of Japanese sporadic Alzheimer's disease.
Neuroscience letters - 26 Apr 2002
Shibata Nobuto, Ohnuma Tohru, Takahashi Tadashi, Baba Hajime, Ishizuka Takuya, Ohtsuka Mieko, Ueki Akira, Nagao Masatsugu, Arai Heii
Abstract excerpt
Interleukin-4 (IL4) is an anti-inflammatory cytokine that may play a role in the inflammation pathology observed surrounding senile plaques, and may also associate with Alzheimer's disease (AD) pathogenesis. Recently, it has been reported that a single nucleotide polymorphism in the IL4 gene promoter region, IL4 +33C/T polymorphism, associates with its phenotype. It was thought that the IL4 +33C/T polymorphism...
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