Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

doi:10.1084/jem.20080669

Article

Polζ ablation in B cells impairs the germinal center reaction, class switch recombination, DNA break repair, and genome stability

9 Feb 2009

Abstract excerpt

Pol zeta is an error-prone DNA polymerase that is critical for embryonic development and maintenance of genome stability. To analyze its suggested role in somatic hypermutation (SHM) and possible contribution to DNA double-strand break (DSB) repair in class switch recombination (CSR), we ablated Rev3, the catalytic subunit of Pol zeta, selectively in mature B cells in vivo. The frequency of somatic mutation was...

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