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Article

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition.

Xenobiotica; the fate of foreign compounds in biological systems - 1 Jul 2008

Zhou S-F

Abstract excerpt

1. P-glycoprotein (P-gp/MDR1), one of the most clinically important transmembrane transporters in humans, is encoded by the ABCB1/MDR1 gene. Recent insights into the structural features of P-gp/MDR1 enable a re-evaluation of the biochemical evidence on the binding and transport of drugs by P-gp/MDR1. 2. P-gp/MDR1 is found in various human tissues in addition to being expressed in tumours cells. It is located on...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Identifiers

PMID: 18668431
DOI: 10.1080/00498250701867889

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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