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Article

Development and Biological Evaluation of a Novel Aurora A Kinase Inhibitor

6 Feb 2009

Abstract excerpt

STOP DIVIDING: In the quest for antitumorigenic compounds, aurora A kinase has recently emerged as a potential drug target. In this paper three novel aurora inhibitors (shown in the illustration) have been tested for their biological activity in cultured cells. One of them (TC-28) appears to be a promising specific aurora A inhibitor in vivo. The aurora kinase family groups several serine/threonine kinases with...

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Identifiers

PMID: 19199284
DOI: 10.1002/cbic.200800600

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