Article
[Neurodegeneration and inflammation: analysis of a FTDP-17 model mouse].
Rinsho shinkeigaku = Clinical neurology - 1 Nov 2008
Yoshiyama Yasumasa
Abstract excerpt
Filamentous tau inclusions are hallmarks of Alzheimer's disease (AD) and related tauopathies, and the discovery of mutations in the tau gene in frontotemporal dementia and parkinsonism linked to chromosome 17 (FTDP-17) constitutes convincing evidence that tau proteins play a key role in the pathogenesis of neurodegenerative disorders. To investigate the pathomechanism of tauopathies, we generated and studied...
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