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Article

Noncanonical mutations in ribosome nascent peptide exit tunnel confer clarithromycin resistance in Mycobacterium abscessus complex.

International journal of antimicrobial agents - 1 Aug 2024

Liao Wei, Wang Xinyan, Wang Yi, Ma Pengjiao, Chen Ken, Ge Liang, Yang Xiaoyan, Zeng Shushu, Gao Wenfeng, Zhang Shu, Wang Hongren, Jia Xu, Luo Tao

Abstract excerpt

OBJECTIVES: Mycobacterium abscessus is a non-tuberculous mycobacterial pathogen that causes pulmonary and skin infections globally. Clarithromycin plays a pivotal role in treating M. abscessus infections, with resistance often leading to treatment failure. While canonical mutations in the 23S rRNA residue 2270/2271 are recognized as the primary mechanism for acquired clarithromycin resistance, resistant isolates...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Mutagenesis, Site-Directed

Share to Mycobacterium Infections, Nontuberculous

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Share to RNA, Ribosomal, 23S

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Source

Identifiers

PMID: 38810940
DOI: 10.1016/j.ijantimicag.2024.107223

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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