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Article

Comment on "Human-specific gain of function in a developmental enhancer".

Science (New York, N.Y.) - 6 Feb 2009

Duret Laurent, Galtier Nicolas

Abstract excerpt

Prabhakar et al. (Reports, 5 September 2008, p. 1346) argued that the conserved noncoding sequence HACNS1 has undergone positive selection and contributed to human adaptation. However, the pattern of substitution in HACNS1 is more consistent with the neutral process of biased gene conversion (BGC). The reported human-specific gain of function is likely due to the accumulation of deleterious mutations driven by...

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Share to Conserved Sequence
Share to Enhancer Elements, Genetic
Share to Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Recombination, Genetic

Share to Selection, Genetic

Source

Identifiers

PMID: 19197042
DOI: 10.1126/science.1165848

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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