Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.

BMC biology - 22 May 2013

Shi Lei, Li Ming, Lin Qiang, Qi Xuebin, Su Bing

Abstract excerpt

BACKGROUND: One of the key genes that regulate human brain size, MCPH1 has evolved under strong Darwinian positive selection during the evolution of primates. During this evolution, the divergence of MCPH1 protein sequences among primates may have caused functional changes that contribute to brai...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle Proteins
Share to Cytoskeletal Proteins
Share to E2F1 Transcription Factor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Macaca mulatta

Share to Mutant Proteins

Share to Nerve Tissue Proteins

Share to Organ Size

Share to Protein Interaction Mapping

Source

Open in PubMed Open full text

Identifiers

PMID: 23697381
DOI: 10.1186/1741-7007-11-62
PMCID: PMC3674976

Genes

MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23697381-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans.PMID 23697381Read ↗

Adaptive evolution of four microcephaly genes and the evolution of brain size in anthropoid primates.Semantic proximity Read ↗

Systematic detection of brain protein-coding genes under positive selection during primate evolution and their roles in cognitionSemantic proximity Read ↗

Regional selection of the brain size regulating gene CASC5 provides new insight into human brain evolution.Semantic proximity Read ↗

Microcephaly genes and the evolution of sexual dimorphism in primate brain size.Semantic proximity Read ↗

Microcephalin, a gene regulating brain size, continues to evolve adaptively in humans.Semantic proximity Read ↗

Estrogen regulation of microcephaly genes and evolution of brain sexual dimorphism in primates.Semantic proximity Read ↗

Accelerated evolution of the ASPM gene controlling brain size begins prior to human brain expansion.Semantic proximity Read ↗

A novel MCPH1 isoform complements the defective chromosome condensation of human MCPH1-deficient cells.Semantic proximity Read ↗

TALEN-based generation of a cynomolgus monkey disease model for human microcephaly.Semantic proximity Read ↗

A common SNP of MCPH1 is associated with cranial volume variation in Chinese population.Semantic proximity Read ↗

Evidence that the adaptive allele of the brain size gene microcephalin introgressed into Homo sapiens from an archaic Homo lineage.Semantic proximity Read ↗

Tempo and mode of gene expression evolution in the brain across PrimatesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.