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Article

Human Accelerated Regions and Other Human-Specific Sequence Variations in the Context of Evolution and Their Relevance for Brain Development.

Genome biology and evolution - 1 Jan 2018

Levchenko Anastasia, Kanapin Alexander, Samsonova Anastasia, Gainetdinov Raul R

Abstract excerpt

The review discusses, in a format of a timeline, the studies of different types of genetic variants, present in Homo sapiens, but absent in all other primate, mammalian, or vertebrate species, tested so far. The main characteristic of these variants is that they are found in regions of high evolutionary conservation. These sequence variations include single nucleotide substitutions (called human accelerated...

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PMID: 29149249
DOI: 10.1093/gbe/evx240
PMCID: PMC5767953

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