Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

M2 macrophage accumulation contributes to pulmonary fibrosis, vascular dilatation, and hypoxemia in rat hepatopulmonary syndrome.

Journal of cellular physiology - 1 Nov 2021

Chen Bing, Yang Yong, Yang Congwen, Duan Jiaxiang, Chen Lin, Lu Kaizhi, Yi Bin, Chen Yang, Xu Duo, Huang He

Abstract excerpt

Hepatopulmonary syndrome (HPS) markedly increases the mortality of patients. However, its pathogenesis remains incompletely understood. Rat HPS develops in common bile duct ligation (CBDL)-induced, but not thioacetamide (TAA)-induced cirrhosis. We investigated the mechanisms of HPS by comparing these two models. Pulmonary histology, blood gas exchange, and the related signals regulating macrophage accumulation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biphenyl Compounds
Share to Dilatation, Pathologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Granulocyte-Macrophage Colony-Stimulating Factor

Share to Microvessels

Share to Neutrophil Infiltration

Share to Pulmonary Fibrosis

Share to Receptors, CCR2

Share to Receptors, Granulocyte-Macrophage Colony-Stimulating Factor

Source

Identifiers

PMID: 34041750
DOI: 10.1002/jcp.30420

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

M2 macrophage accumulation contributes to pulmonary fibrosis, vascular dilatation, and hypoxemia in rat hepatopulmonary syndrome.PMID 34041750Read ↗

Leukocytes, Systemic Inflammation and Immunopathology in Acute-on-Chronic Liver Failure.Semantic proximity Read ↗

PPARγ-dependent hepatic macrophage switching acts as a central hub for hUCMSCs-mediated alleviation of decompensated liver cirrhosis in ratsSemantic proximity Read ↗

Hepatocytes-derived Prdx1 regulates macrophage phenotypes via TLR4 activation in acute liver injury.Semantic proximity Read ↗

Therapeutic Role of Inducible Nitric Oxide Synthase Expressing Myeloid-Derived Suppressor Cells in Acetaminophen-Induced Murine Liver Failure.Semantic proximity Read ↗

The spleen as an extramedullary source of inflammatory cells responding to acetaminophen-induced liver injury.Semantic proximity Read ↗

Enhanced meningeal lymphatic drainage ameliorates neuroinflammation and hepatic encephalopathy in cirrhotic ratsSemantic proximity Read ↗

TNF-α/HMGB1 inflammation signalling pathway regulates pyroptosis during liver failure and acute kidney injury.Semantic proximity Read ↗

Emerging Importance of Chemokine Receptor CXCR4 and Its Ligand in Liver DiseaseSemantic proximity Read ↗

Annexin A1 protein regulates the expression of PMVEC cytoskeletal proteins in CBDL rat serum-induced pulmonary microvascular remodeling.Semantic proximity Read ↗

Hepatic Arterial Flow-Induced Portal Tract Fibrosis in Portal Hypertension: The Role of VCAM-1 and Osteopontin-Expressing MacrophagesSemantic proximity Read ↗

Roles of CCR2 and CCR5 for Hepatic Macrophage Polarization in Mice With Liver Parenchymal Cell-Specific NEMO DeletionSemantic proximity Read ↗

Depletion of Natural Killer Cells improve cholestasis in a murine model of primary biliary cholangitisSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.