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Article

Lymphopenia in Ednrb-deficient rat was strongly modified by genetic background.

Biomedical research (Tokyo, Japan) - 1 Jan 2012

Dang Ruihua, Sasaki Nobuya, Nishino Tomohiro, Nakanishi Moe, Torigoe Daisuke, Agui Takashi

Abstract excerpt

The endothelin signaling pathway plays an important role in the migration, proliferation, and differentiation of neural crest cells. Mutations in the gene encoding the endothelin receptor type B (EDNRB) cause three symptoms: aganglionosis, pigmented disorder and hearing loss. In addition, the Ednrb null mice show abnormal splenic microarchitecture with lymphopenia. In this study, we examined whether similar...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22975636
DOI: 10.2220/biomedres.33.249

Genes

EDNRB

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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