Article
Transgenic expression of Angiopoietin 1 in the liver leads to changes in lymphatic and blood vessel architecture.
Biochemical and biophysical research communications - 14 Jul 2006
Haninec Alexandra L, Voskas Daniel, Needles Andrew, Brown Allison S, Foster F Stuart, Dumont Daniel J
Abstract excerpt
To investigate the possible role of the Angiopoietins in vessel remodelling, we overexpressed one of the angiopoietins, Angiopoietin-1 (Ang1), in the hepatocytes of mice by means of the conditional binary transgenic system. Animals were examined by Doppler ultrasound, and dissected livers were analyzed by immunohistochemical staining. Double transgenic mice presented with enlarged spleens and kidneys, enlarged,...
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