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Article

MPLW515L mutation in acute megakaryoblastic leukaemia.

Leukemia - 1 May 2009

Hussein K, Bock O, Theophile K, Schulz-Bischof K, Porwit A, Schlue J, Jonigk D, Kreipe H

Abstract excerpt

The thrombopoietin receptor gene (MPL) is expressed in megakaryocytes and exhibits the gain of function point mutation W515K/L in approximately 5% of patients with primary myelofibrosis/idiopathic myelofibrosis (PMF) representing one subtype of the chronic myeloproliferative disorders (myeloproliferative neoplasm). A series of primary and secondary acute myeloid leukaemias (AML) with megakaryoblastic phenotype...

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Source

Identifiers

PMID: 19194467
DOI: 10.1038/leu.2008.371

Genes

MPL

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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MPLW515L mutation in acute megakaryoblastic leukaemia.PMID 19194467Read ↗

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New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition.Semantic proximity Read ↗

A sensitive detection method for MPLW515L or MPLW515K mutation in chronic myeloproliferative disorders with locked nucleic acid-modified probes and real-time polymerase chain reaction.Semantic proximity Read ↗

Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients.Semantic proximity Read ↗

Rapid real-time PCR assay for detection of MPL W515L mutation in patients with chronic myeloproliferative disorders.Semantic proximity Read ↗

MPL W515L/K mutations in 343 Chinese adults with JAK2V617F mutation-negative chronic myeloproliferative disorders detected by a newly developed RQ-PCR based on TaqMan MGB probes.Semantic proximity Read ↗

Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.Semantic proximity Read ↗

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