Article
Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients.
Leukemia - 1 Dec 2011
Pardanani A, Guglielmelli P, Lasho T L, Pancrazzi A, Finke C M, Vannucchi A M, Tefferi A
Abstract excerpt
MPL and JAK2V617F mutation analysis was performed in 603 patients with primary myelofibrosis (PMF) seen at the Mayo Clinic, USA (n=329) or University of Florence, Italy (n=274). Mutant MPL was detected in 49 (8.1%) patients and JAK2V617F in 350 (58%); 4 patients showed both mutations. MPLW515L/K was the commonest mutation; 2 patients showed novel mutations (L513ins and Q516-P518insAAAA). The US and Italy patient...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.