Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition.

Leukemia - 1 Aug 2008

Chaligné R, Tonetti C, Besancenot R, Roy L, Marty C, Mossuz P, Kiladjian J-J, Socié G, Bordessoule D, Le Bousse-Kerdilès M-C, Vainchenker W, Giraudier S

Abstract excerpt

MPL (or thrombopoietin receptor, TPO-R) 515 mutations have recently been described in 5-10% of primitive myelofibrosis (PMF) cases as decisive oncogenic events capable of triggering the disease. Here we report additional mutations located in exon 10 of MPL in PMF patients. We investigated whether these new mutations also lead to cell transformation. MPL exon 10 was systematically sequenced in 100 PMF patients....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Cell Proliferation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to G1 Phase

Share to Mice, Nude

Share to Primary Myelofibrosis

Share to Receptors, Thrombopoietin

Share to S Phase

Share to Signal Transduction

Source

Identifiers

PMID: 18528423
DOI: 10.1038/leu.2008.137

Genes

MPL
JAK2
TPO

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

New mutations of MPL in primitive myelofibrosis: only the MPL W515 mutations promote a G1/S-phase transition.PMID 18528423Read ↗

Novel drivers and modifiers of MPL-dependent oncogenic transformation identified by deep mutational scanning.Semantic proximity Read ↗

Evidence for MPL W515L/K mutations in hematopoietic stem cells in primitive myelofibrosis.Semantic proximity Read ↗

Molecular mechanisms associated with leukemic transformation of MPL-mutant myeloproliferative neoplasms.Semantic proximity Read ↗

MPLW515L mutation in acute megakaryoblastic leukaemia.Semantic proximity Read ↗

MPL mutations in myeloproliferative disorders: analysis of the PT-1 cohort.Semantic proximity Read ↗

MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients.Semantic proximity Read ↗

Primary myelofibrosis with or without mutant MPL: comparison of survival and clinical features involving 603 patients.Semantic proximity Read ↗

Acquired copy-neutral loss of heterozygosity of chromosome 1p as a molecular event associated with marrow fibrosis in MPL-mutated myeloproliferative neoplasmsSemantic proximity Read ↗

Screening for MPL mutations in essential thrombocythemia and primary myelofibrosis: normal Mpl expression and absence of constitutive STAT3 and STAT5 activation in MPLW515L-positive platelets.Semantic proximity Read ↗

MPL exon 10 mutations other than canonical MPL W515L/K mutations identified by in-house MPL exon 10 direct sequencing in essential thrombocythemia.Semantic proximity Read ↗

Leukemic blasts in transformed JAK2-V617F-positive myeloproliferative disorders are frequently negative for the JAK2-V617F mutation.Semantic proximity Read ↗

Detection of MPL exon10 mutations in 103 Chinese patients with JAK2V617F-negative myeloproliferative neoplasms.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.