Article
UV irradiation drives lineage-specific MITF-mediated transcription of PD-L1 to confer immune tolerance to UV-mutated melanocytes.
Immunity - 8 Sept 2026
Lo Jennifer A, Rachmin Inbal, Flesher Jessica L, Wu Xunwei, Kawakami Akinori, Hejna Miroslav, Boozer Judith R, Nguyen Nhu, King Andrew D, Ji Yawen, Germana Sharon, Kemeny Lajos V, van der Sande Anita A J, Cheng Jeffrey B, Lotem Michal, Utne Torrey R, Zhan Yao, Roider Elisabeth M, Mujahid Nisma, Byrne Elizabeth H, Singh Shailbala, Saidani Manoubia, Martineau Sabrina, Holic Nathalie, Baldeschi Christine, Martinat Cécile, Freeman Gordon J, Hacohen Nir, Flaherty Keith T, Boland Genevieve M, Song Jun S, Sharpe Arlene H, Demehri Shadmehr, Yee Cassian, Allouche Jennifer, Fisher David E
Abstract excerpt
UV radiation (UVR) drives high mutational burdens, yet precursor melanocytes accumulate these mutations without triggering immune clearance. Here, we investigated whether melanocyte-intrinsic transcriptional program(s) underlie immune tolerance to mutations resulting from UVR exposure. In primary human melanocytes, expression of PD-L1 (CD274) was dependent on microphthalmia-associated transcription factor (MITF),...
Read the complete abstract on PubMedTopics
- Melanocytes
- Microphthalmia-Associated Transcription Factor