Article
Prediction of BRCA Mutations Using the BRCAPRO Model in Clinic-Based African American, Hispanic, and Other Minority Families in the United States.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Mar 2009
Huo Dezheng, Senie Ruby T, Daly Mary, Buys Saundra S, Cummings Shelly, Ogutha Jacqueline, Hope Kisha, Olopade Olufunmilayo I
Abstract excerpt
PURPOSE: BRCAPRO, a BRCA mutation carrier prediction model, was developed on the basis of studies in individuals of Ashkenazi Jewish and European ancestry. We evaluated the performance of the BRCAPRO model among clinic-based minority families. We also assessed the clinical utility of mutation status of probands (the first individual tested in a family) in the recommendation of BRCA mutation testing for other...
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