Article
Genetic testing in an ethnically diverse cohort of high-risk women: a comparative analysis of BRCA1 and BRCA2 mutations in American families of European and African ancestry.
JAMA - 19 Oct 2005
Nanda Rita, Schumm L Philip, Cummings Shelly, Fackenthal James D, Sveen Lise, Ademuyiwa Foluso, Cobleigh Melody, Esserman Laura, Lindor Noralane M, Neuhausen Susan L, Olopade Olufunmilayo I
Abstract excerpt
CONTEXT: Ten years after BRCA1 and BRCA2 were first identified as major breast cancer susceptibility genes, the spectrum of mutations and modifiers of risk among many ethnic minorities remain undefined. OBJECTIVES: To characterize the clinical predictors, spectrum, and frequency of BRCA1 and BRCA2 mutations in an ethnically diverse high-risk clinic population and to evaluate the performance of the BRCAPRO...
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