Article
BRCA1 and BRCA2 genetic testing in Hispanic patients: mutation prevalence and evaluation of the BRCAPRO risk assessment model.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Oct 2007
Vogel Kristen J, Atchley Deann P, Erlichman Julie, Broglio Kristine R, Ready Kaylene J, Valero Vicente, Amos Christopher I, Hortobagyi Gabriel N, Lu Karen H, Arun Banu
Abstract excerpt
PURPOSE: The BRCAPRO model, used to predict a family's likelihood of carrying a BRCA1 or BRCA2 mutation, was designed using mutation frequencies of white and Ashkenazi Jewish populations, and may not be applicable to other populations. BRCAPRO was recently validated in African Americans, although has yet to be examined in Hispanics. This retrospective study reports the mutation frequency and spectrum of BRCA1 and...
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