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Article

In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection.

European journal of immunology - 1 Feb 2005

Takahashi Shigekazu, Kataoka Hiroshi, Hara Satoru, Yokosuka Tadashi, Takase Kan, Yamasaki Sho, Kobayashi Wakana, Saito Yasushi, Saito Takashi

Abstract excerpt

Cytotoxic T lymphocyte antigen-4 (CTLA-4) induces major inhibitory signals for T cell activation. From analyses of TCR-transgenic (Tg) CTLA-4-deficient mice, it has been believed that CTLA-4 does not affect thymocyte development. To focus upon the in vivo function of CTLA-4 in thymocyte development from a different aspect, we have established Tg mice expressing either full-length CTLA-4 (FL-Tg) or a mutant CTLA-4...

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Source

Identifiers

PMID: 15668914
DOI: 10.1002/eji.200324746

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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In vivo overexpression of CTLA-4 suppresses lymphoproliferative diseases and thymic negative selection.PMID 15668914Read ↗

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