TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia.

doi:10.1158/1078-0432.CCR-21-0701

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Article

TP53 Mutations with Low Variant Allele Frequency Predict Short Survival in Chronic Lymphocytic Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 15 Oct 2021

Bomben Riccardo, Rossi Francesca Maria, Vit Filippo, Bittolo Tamara, D'Agaro Tiziana, Zucchetto Antonella, Tissino Erika, Pozzo Federico, Vendramini Elena, Degan Massimo, Zaina Eva, Cattarossi Ilaria, Varaschin Paola, Nanni Paola, Berton Michele, Braida Alessandra, Polesel Jerry, Cohen Jared A, Santinelli Enrico, Biagi Annalisa, Gentile Massimo, Morabito Fortunato, Fronza Gilberto, Pozzato Gabriele, D'Arena Giovanni, Olivieri Jacopo, Bulian Pietro, Pepper Chris, Hockaday Anna, Schuh Anna, Hillmen Peter, Rossi Davide, Chiarenza Annalisa, Zaja Francesco, Di Raimondo Francesco, Del Poeta Giovanni, Gattei Valter

Abstract excerpt

PURPOSE: In chronic lymphocytic leukemia (CLL), TP53 mutations are associated with reduced survival and resistance to standard chemoimmunotherapy (CIT). Nevertheless, the clinical impact of subclonal TP53 mutations below 10% to 15% variant allele frequency (VAF) remains unclear. EXPERIMENTAL DESIGN: Using a training/validation approach, we retrospectively analyzed the clinical and biological features of TP53...

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PMID: 34285062
DOI: 10.1158/1078-0432.CCR-21-0701

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