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Article

A shift of dynamic equilibrium between the KIT active and inactive states causes drug resistance.

Proteins - 1 Nov 2020

Srikakulam Sanjay K, Bastys Tomas, Kalinina Olga V

Abstract excerpt

Tyrosine phosphorylation, a highly regulated post-translational modification, is carried out by the enzyme tyrosine kinase (TK). TKs are important mediators in signaling cascades, facilitating diverse biological processes in response to stimuli. TKs may acquire mutations leading to malignancy and are viable targets for anti-cancer drugs. Mast/stem cell growth factor receptor KIT is a TK involved in cell...

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PMID: 32530065
DOI: 10.1002/prot.25963

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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