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Article

A nonessential role for Arg 55 in cyclophilin18 for catalysis of proline isomerization during protein folding.

Protein science : a publication of the Protein Society - 1 Feb 2009

Moparthi Satish Babu, Hammarström Per, Carlsson Uno

Abstract excerpt

The protein folding process is often in vitro rate-limited by slow cis-trans proline isomerization steps. Importantly, the rate of this process in vivo is accelerated by prolyl isomerases (PPIases). The archetypal PPIase is the human cyclophilin 18 (Cyp18 or CypA), and Arg 55 has been demonstrated to play a crucial role when studying short peptide substrates in the catalytic action of Cyp18 by stabilizing the...

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Identifiers

PMID: 19185003
DOI: 10.1002/pro.28
PMCID: PMC2708058

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