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Article

Kinetic mechanism and catalysis of a native-state prolyl isomerization reaction.

Journal of molecular biology - 7 Feb 2003

Pappenberger Günter, Bachmann Annett, Müller Rita, Aygün Hüseyin, Engels Joachim W, Kiefhaber Thomas

Abstract excerpt

Folding of tendamistat is a rapid two-state process for the majority of the unfolded molecules. In fluorescence-monitored refolding kinetics about 8% of the unfolded molecules fold slowly (lambda=0.083s(-1)), limited by peptidyl-prolyl cis-trans isomerization. This is significantly less than expected from the presence of three trans prolyl-peptide bonds in the native state. In interrupted refolding experiments we...

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Source

Identifiers

PMID: 12547205
DOI: 10.1016/s0022-2836(02)01373-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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