Characterization of folding intermediates using prolyl isomerase.

doi:10.1021/bi00169a009

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Article

Characterization of folding intermediates using prolyl isomerase.

Biochemistry - 25 Jan 1994

Veeraraghavan S, Nall B T

Abstract excerpt

Structure-reactivity relationships of human peptidyl prolyl cis-trans isomerase (PPI) toward the two slow folding reactions of yeast iso-2 cytochrome c have been used to characterize the structure of folding intermediates in the vicinity of critical prolines. We propose that the relative catalyti...

Topics

Amino Acid Isomerases
Carrier Proteins
Catalysis
Cytochrome c Group
Cytochromes c
Guanidine
Guanidines
Models, Chemical
Mutation
Peptidylprolyl Isomerase
Proline
Protein Denaturation
Protein Folding
Saccharomyces cerevisiae
Time Factors

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