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Article

Multiple roles of prolyl residues in structure and folding.

Journal of molecular biology - 18 Aug 2000

Eyles S J, Gierasch L M

Abstract excerpt

To explore the ways that proline residues may influence the conformational options of a polypeptide backbone, we have characterized Pro-->Ala mutants of cellular retinoic acid-binding protein I (CRABP I). While all three Xaa-Pro bonds are in the trans conformation in the native protein and the equilibrium stability of each mutant is similar to that of the parent protein, each has distinct effects on folding and...

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Identifiers

PMID: 10966780
DOI: 10.1006/jmbi.2000.4002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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