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Article

The autoimmunity of primary biliary cirrhosis and the clonal selection theory

26 Oct 2010

Abstract excerpt

Primary biliary cirrhosis (PBC) is a chronic cholestatic liver disease in which an immune-mediated injury targets the small intrahepatic bile ducts. PBC is further characterized by highly specific serum antimitochondrial autoantibodies (AMAs) and autoreactive T cells, a striking female predominance, a strong genetic susceptibility and a plethora of candidate environmental factors to trigger the disease onset. For...

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PMID: 20975735
DOI: 10.1038/icb.2010.126

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