Article
Use of weighted reference panels based on empirical estimates of ancestry for capturing untyped variation.
Human genetics - 1 Apr 2009
Egyud Matthew R L, Gajdos Zofia K Z, Butler Johannah L, Tischfield Sam, Le Marchand Loic, Kolonel Laurence N, Haiman Christopher A, Henderson Brian E, Hirschhorn Joel N
Abstract excerpt
Many association methods use a subset of genotyped single nucleotide polymorphisms (SNPs) to capture or infer genotypes at other untyped SNPs. We and others previously showed that tag SNPs selected to capture common variation using data from The International HapMap Consortium (Nature 437:1299-1320, 2005), The International HapMap Consortium (Nature 449:851-861, 2007) could also capture variation in populations...
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