Article
Improving power of association tests using multiple sets of imputed genotypes from distributed reference panels.
Genetic epidemiology - 1 Dec 2017
Zhou Wei, Fritsche Lars G, Das Sayantan, Zhang He, Nielsen Jonas B, Holmen Oddgeir L, Chen Jin, Lin Maoxuan, Elvestad Maiken B, Hveem Kristian, Abecasis Goncalo R, Kang Hyun Min, Willer Cristen J
Abstract excerpt
The accuracy of genotype imputation depends upon two factors: the sample size of the reference panel and the genetic similarity between the reference panel and the target samples. When multiple reference panels are not consented to combine together, it is unclear how to combine the imputation results to optimize the power of genetic association studies. We compared the accuracy of 9,265 Norwegian genomes imputed...
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