Article
An ancestry informative marker panel design for individual ancestry estimation of Hispanic population using whole exome sequencing data.
BMC genomics - 30 Dec 2019
Wang Li-Ju, Zhang Catherine W, Su Sophia C, Chen Hung-I H, Chiu Yu-Chiao, Lai Zhao, Bouamar Hakim, Ramirez Amelie G, Cigarroa Francisco G, Sun Lu-Zhe, Chen Yidong
Abstract excerpt
BACKGROUND: Europeans and American Indians were major genetic ancestry of Hispanics in the U.S. These ancestral groups have markedly different incidence rates and outcomes in many types of cancers. Therefore, the genetic admixture may cause biased genetic association study with cancer susceptibility variants specifically in Hispanics. For example, the incidence rate of liver cancer has been shown with substantial...
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