Article
Rapid assessment of genetic ancestry in populations of unknown origin by genome-wide genotyping of pooled samples.
PLoS genetics - 5 Mar 2010
Chiang Charleston W K, Gajdos Zofia K Z, Korn Joshua M, Kuruvilla Finny G, Butler Johannah L, Hackett Rachel, Guiducci Candace, Nguyen Thutrang T, Wilks Rainford, Forrester Terrence, Haiman Christopher A, Henderson Katherine D, Le Marchand Loic, Henderson Brian E, Palmert Mark R, McKenzie Colin A, Lyon Helen N, Cooper Richard S, Zhu Xiaofeng, Hirschhorn Joel N
Abstract excerpt
As we move forward from the current generation of genome-wide association (GWA) studies, additional cohorts of different ancestries will be studied to increase power, fine map association signals, and generalize association results to additional populations. Knowledge of genetic ancestry as well as population substructure will become increasingly important for GWA studies in populations of unknown ancestry. Here...
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