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Article

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway.

Molecular and cellular biology - 1 Jan 2012

Nishiyama Masaaki, Skoultchi Arthur I, Nakayama Keiichi I

Abstract excerpt

Members of the chromodomain helicase DNA-binding (CHD) family of proteins are thought to regulate gene expression. Among mammalian CHD proteins, CHD8 was originally isolated as a negative regulator of the Wnt-β-catenin signaling pathway that binds directly to β-catenin and suppresses its transactivation activity. The mechanism by which CHD8 inhibits β-catenin-dependent transcription has been unclear, however....

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Source

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Identifiers

PMID: 22083958
DOI: 10.1128/MCB.06409-11
PMCID: PMC3255766

Genes

CHD8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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