Article
Array comparative genomic hybridization in retinoma and retinoblastoma tissues.
Cancer science - 1 Mar 2009
Sampieri Katia, Amenduni Mariangela, Papa Filomena Tiziana, Katzaki Eleni, Mencarelli Maria Antonietta, Marozza Annabella, Epistolato Maria Carmela, Toti Paolo, Lazzi Stefano, Bruttini Mirella, De Filippis Roberta, De Francesco Sonia, Longo Ilaria, Meloni Ilaria, Mari Francesca, Acquaviva Antonio, Hadjistilianou Theodora, Renieri Alessandra, Ariani Francesca
Abstract excerpt
In retinoblastoma, two RB1 mutations are necessary for tumor development. Recurrent genomic rearrangements may represent subsequent events required for retinoblastoma progression. Array-comparative genomic hybridization was carried out in 18 eye samples, 10 from bilateral and eight from unilateral retinoblastoma patients. Two unilateral cases also showed areas of retinoma. The most frequent imbalance in...
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