Molecular alterations in retinoblastoma beyond RB1.

doi:10.1016/j.exer.2021.108753

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Article

Molecular alterations in retinoblastoma beyond RB1.

Experimental eye research - 1 Oct 2021

Mendonça Vanessa, Evangelista Anna Claudia, P Matta Bruna, M Moreira Miguel Ângelo, Faria Paulo, Lucena Evandro, Seuánez Héctor N

Abstract excerpt

Retinoblastoma is the most common malignant ocular tumor in children. Although RB1 alterations are most frequently involved in the etiology of retinoblastoma, candidate driver events and somatic alterations leading to cell transformation, tumor onset and progression remain poorly understood. In this study, we identified novel genomic alterations in tumors with a panel of 160 genes. Sanger sequencing and Multiplex...

Topics

Alleles
Child, Preschool
DNA Copy Number Variations
DNA Mutational Analysis
Exons
Female
Genes, Neoplasm
Humans
Infant
Male
Molecular Biology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multiplex Polymerase Chain Reaction

Mutation

Neoplasm Proteins

Retinal Neoplasms

Retinoblastoma

Retinoblastoma Binding Proteins

Sequence Analysis, DNA

Source

Open in PubMed

Identifiers

PMID: 34478740
DOI: 10.1016/j.exer.2021.108753

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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