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Genetic and Epigenetic Discoveries in Human Retinoblastoma

1 Jan 2015

Abstract excerpt

Retinoblastoma is a rare pediatric cancer of the retina. Nearly all retinoblastomas are initiated through the biallelic inactivation of the retinoblastoma tumor susceptibility gene (RB1). Whole-genome sequencing has made it possible to identify secondary genetic lesions following RB1 inactivation. One of the major discoveries from retinoblastoma sequencing studies is that some retinoblastoma tumors have stable...

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PMID: 26349417
DOI: 10.1615/critrevoncog.2015013711

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