Article
Genomic and Transcriptomic Tumor Heterogeneity in Bilateral Retinoblastoma.
JAMA ophthalmology - 1 May 2020
Winter Ursula, Ganiewich Daiana, Ottaviani Daniela, Zugbi Santiago, Aschero Rosario, Sendoya Juan Martin, Cafferata Eduardo G, Mena Marcela, Sgroi Mariana, Sampor Claudia, Lubieniecki Fabiana, Fandiño Adriana, Abba Martin C, Doz François, Podhjacer Osvaldo, Carcaboso Angel Montero, Letouzé Eric, Radvanyi François, Chantada Guillermo L, Llera Andrea S, Schaiquevich Paula
Abstract excerpt
Importance: Comprehensive understanding of the genomic and gene-expression differences between retinoblastoma tumors from patients with bilateral disease may help to characterize risk and optimize treatment according to individual tumor characteristics. Objective: To compare the genomic features between each eye and a specimen from an orbital relapse in patients with bilateral retinoblastoma. Design, Setting, and...
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