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Article

Solution hybrid selection with ultra-long oligonucleotides for massively parallel targeted sequencing.

Nature biotechnology - 1 Feb 2009

Gnirke Andreas, Melnikov Alexandre, Maguire Jared, Rogov Peter, LeProust Emily M, Brockman William, Fennell Timothy, Giannoukos Georgia, Fisher Sheila, Russ Carsten, Gabriel Stacey, Jaffe David B, Lander Eric S, Nusbaum Chad

Abstract excerpt

Targeting genomic loci by massively parallel sequencing requires new methods to enrich templates to be sequenced. We developed a capture method that uses biotinylated RNA 'baits' to fish targets out of a 'pond' of DNA fragments. The RNA is transcribed from PCR-amplified oligodeoxynucleotides orig...

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PMID: 19182786
DOI: 10.1038/nbt.1523
PMCID: PMC2663421

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19182786-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

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