Article
Multiplex amplification of large sets of human exons.
Nature methods - 1 Nov 2007
Porreca Gregory J, Zhang Kun, Li Jin Billy, Xie Bin, Austin Derek, Vassallo Sara L, LeProust Emily M, Peck Bill J, Emig Christopher J, Dahl Fredrik, Gao Yuan, Church George M, Shendure Jay
Abstract excerpt
A new generation of technologies is poised to reduce DNA sequencing costs by several orders of magnitude. But our ability to fully leverage the power of these technologies is crippled by the absence of suitable 'front-end' methods for isolating complex subsets of a mammalian genome at a scale that matches the throughput at which these platforms will routinely operate. We show that targeting oligonucleotides...
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