Article
Polymorphisms in the promoter region of the human class II alcohol dehydrogenase (ADH4) gene affect both transcriptional activity and ethanol metabolism in Japanese subjects.
The Journal of toxicological sciences - 1 Feb 2009
Kimura Yukiko, Nishimura Fusae T, Abe Shuntaro, Fukunaga Tatsushige, Tanii Hideji, Saijoh Kiyofumi
Abstract excerpt
Class II alcohol dehydrogenase (pi-ADH), encoded by alcohol dehydrogenase (ADH4), is considered to contribute to ethanol (EtOH) oxidation in the liver at high concentration. Four single nucleotide polymorphisms (SNPs) were found in the promoter region of this gene. Analysis of genotype distribution in 102 unrelated Japanese subjects revealed that four loci were in strong linkage disequilibrium and could be...
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