Variation in the ADH1B proximal promoter affects expression.

doi:10.1016/j.cbi.2010.12.007

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Article

Variation in the ADH1B proximal promoter affects expression.

Chemico-biological interactions - 30 May 2011

Pochareddy Sirisha, Edenberg Howard J

Abstract excerpt

The primary pathway of metabolism of dietary alcohol is via its oxidation in liver by alcohol dehydrogenases (ADH). Differences in the ADH enzyme activity or levels of enzyme present could affect the risk for alcoholism. Regulatory variations have been shown to affect the promoter activity and thereby affect the risk for alcoholism. In this study the functional effects of the two SNPs (rs1159918 and rs1229982) in...

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PMID: 21168396
DOI: 10.1016/j.cbi.2010.12.007
PMCID: PMC3075324

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