Article
Validation of a rapid and inexpensive allele-specific amplification (ASA)-PCR genotyping assay for vitamin K antagonist pharmacogenomics.
Molecular diagnosis & therapy - 1 Feb 2011
Spohn Gabriele, Geisen Christof, Luxembourg Beate, Sittinger Katja, Seifried Erhard, Bönig Halvard
Abstract excerpt
BACKGROUND: Variant alleles of vitamin K epoxide reductase complex subunit 1 gene (VKORC1), the target molecule of vitamin K antagonists, and of cytochrome P450 (CYP) 2C9, an enzyme involved in coumarin metabolism, affect the anticoagulant response of coumarins, which have a narrow therapeutic window. Genotyping for these variants allows for prediction of therapeutic drug doses. The discussion of the clinical...
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