Article
A major thyroid hormone response element in the third intron of the rat growth hormone gene.
The EMBO journal - 1 Mar 1990
Sap J, de Magistris L, Stunnenberg H, Vennström B
Abstract excerpt
The rat growth hormone (RGH) gene constitutes a well-documented model system for the direct regulation of transcription by thyroid hormones. In order to analyse its interaction with sequences in the RGH gene, we have overproduced the thyroid hormone receptor-alpha (c-erbA) protein using a vaccinia virus expression system. The expressed protein bound T3 and DNA-cellulose with expected affinities, and the major...
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