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Article

The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.

Obesity (Silver Spring, Md.) - 1 Apr 2009

Lappalainen Tiina J, Tolppanen Anna-Maija, Kolehmainen Marjukka, Schwab Ursula, Lindström Jaana, Tuomilehto Jaakko, Pulkkinen Leena, Eriksson Johan G, Laakso Markku, Gylling Helena, Uusitupa Matti

Abstract excerpt

The common single-nucleotide polymorphism in the FTO (fat mass and obesity associated) gene is consistently associated with an increased risk of obesity. However, the knowledge of a potential modifying effect of the FTO gene on changes in body weight achieved by lifestyle intervention is limited....

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Source

Identifiers

PMID: 19180072
DOI: 10.1038/oby.2008.618

Genes

FTO

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-19180072-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study.PMID 19180072Read ↗

A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity.Semantic proximity Read ↗

Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.Semantic proximity Read ↗

Association of the fat mass and obesity-associated (FTO) gene variant (rs9939609) with dietary intake in the Finnish Diabetes Prevention Study.Semantic proximity Read ↗

FTO genotype and weight loss in diet and lifestyle interventions: a systematic review and meta-analysis.Semantic proximity Read ↗

Common variation in the fat mass and obesity-associated (FTO) gene confers risk of obesity and modulates BMI in the Chinese population.Semantic proximity Read ↗

The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients.Semantic proximity Read ↗

The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet.Semantic proximity Read ↗

The sex-specific influence of FTO genotype on exercise intervention for weight loss in adult with obesity.Semantic proximity Read ↗

Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women.Semantic proximity Read ↗

FTO polymorphisms are associated with obesity but not diabetes risk in postmenopausal women.Semantic proximity Read ↗

The common FTO variant rs9939609 is not associated with BMI in a longitudinal study on a cohort of Swedish men born 1920-1924.Semantic proximity Read ↗

Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss.Semantic proximity Read ↗

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