Article
Common variation in the FTO gene alters diabetes-related metabolic traits to the extent expected given its effect on BMI.
Diabetes - 1 May 2008
Freathy Rachel M, Timpson Nicholas J, Lawlor Debbie A, Pouta Anneli, Ben-Shlomo Yoav, Ruokonen Aimo, Ebrahim Shah, Shields Beverley, Zeggini Eleftheria, Weedon Michael N, Lindgren Cecilia M, Lango Hana, Melzer David, Ferrucci Luigi, Paolisso Giuseppe, Neville Matthew J, Karpe Fredrik, Palmer Colin N A, Morris Andrew D, Elliott Paul, Jarvelin Marjo-Riitta, Smith George Davey, McCarthy Mark I, Hattersley Andrew T, Frayling Timothy M
Abstract excerpt
OBJECTIVE: Common variation in the FTO gene is associated with BMI and type 2 diabetes. Increased BMI is associated with diabetes risk factors, including raised insulin, glucose, and triglycerides. We aimed to test whether FTO genotype is associated with variation in these metabolic traits. RESEARCH DESIGN AND METHODS: We tested the association between FTO genotype and 10 metabolic traits using data from 17,037...
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