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Article

Transcriptional regulation of urokinase-type plasminogen activator receptor by hypoxia-inducible factor 1 is crucial for invasion of pancreatic and liver cancer.

Neoplasia (New York, N.Y.) - 1 Feb 2009

Büchler Peter, Reber Howard A, Tomlinson James S, Hankinson Oliver, Kallifatidis Georgis, Friess Helmut, Herr Ingrid, Hines Oscar J

Abstract excerpt

Angioinvasion is critical for metastasis with urokinase-type plasminogen activator receptor (uPAR) and tumor hypoxia-activated hypoxia-inducible factor 1 (HIF-1) as key players. Transcriptional control of uPAR expression by HIF has never been reported. The aim of the present study, therefore, was to test whether tumor hypoxia-induced HIF expression may be linked to transcriptional activation of uPAR and dependent...

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Identifiers

PMID: 19177204
DOI: 10.1593/neo.08734
PMCID: PMC2631144

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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