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Article

Enhanced ovarian cancer tumorigenesis and metastasis by the macrophage colony-stimulating factor.

Neoplasia (New York, N.Y.) - 1 Feb 2009

Toy Eugene P, Azodi Masoud, Folk Nancy L, Zito Christina M, Zeiss Caroline J, Chambers Setsuko K

Abstract excerpt

Coexpression of the macrophage colony-stimulating factor (CSF-1) and its receptor (CSF-1R) in metastatic ovarian cancer specimens is a predictor of poor outcome in epithelial ovarian cancer. This suggests that an autocrine loop is produced by which ovarian tumors can secrete CSF-1 stimulating the CSF-1R resulting in a more aggressive phenotype. Our current work sought to validate this autocrine stimulation model...

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Identifiers

PMID: 19177198
DOI: 10.1593/neo.81150
PMCID: PMC2631138

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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