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Article

Aberrant epigenetic regulation of GABRP associates with aggressive phenotype of ovarian cancer.

Experimental & molecular medicine - 19 May 2017

Sung Hye Youn, Yang San-Duk, Ju Woong, Ahn Jung-Hyuck

Abstract excerpt

Metastasis is a major cause of therapeutic failure in ovarian cancer. To elucidate molecular mechanisms of ovarian cancer metastasis, we previously established a metastatic xenograft mouse model using human ovarian carcinoma SK-OV-3 cells. Using gene expression profiling, we found that γ-aminobutyric acid (GABA)A receptor π subunit (GABRP) expression was upregulated (>4-fold) in metastatic tissues from our...

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Source

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Identifiers

PMID: 28524180
DOI: 10.1038/emm.2017.62
PMCID: PMC5454450

Genes

GABRP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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