Article
Contrasting expression of thrombospondin-1 and osteopontin correlates with absence or presence of metastatic phenotype in an isogenic model of spontaneous human breast cancer metastasis.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jan 2002
Urquidi Virginia, Sloan Derek, Kawai Kanji, Agarwal Dianne, Woodman Anthony C, Tarin David, Goodison Steve
Abstract excerpt
Knowledge of the molecular mechanisms involved in metastatic spread is needed to facilitate advances in prognostic evaluation for individual patients and in the design of therapeutic interventions to inhibit the process. In an effort to establish a methodological framework for analysis of molecules and mechanisms involved in this complex multistep process, we have developed a well defined experimental system, in...
Topics
- Animals
- Biomarkers, Tumor
- Breast Neoplasms
- Cell Division
- Cell Survival
- DNA Primers
- Disease Progression
- Female
- Gene Expression Regulation, Neoplastic
- Humans
- Hyaluronan Receptors
- Immunoenzyme Techniques